Sodium Hydroxide → 2-(2-(4-Cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid

HRID 470378ノート

反応式

HRID 470378 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([S:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1)#[N:2].[OH-].[Na+]>CO>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([S:15][C:16]([CH3:23])([CH3:22])[C:17]([OH:19])=[O:18])=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1)#[N:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67997044Ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate

生成物 1

HCID 679973632-(2-(4-Cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid収率 96.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

A mixture of ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.137 g, 0.42 mmol), aqueous sodium hydroxide solution (1M, 1 mL) and methanol (2 mL) was stirred at 60° C. for 12 hours. The reaction mixture was concentrated to remove methanol, acidified and filtered to obtain 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid as a white powder (0.121 g, 96%).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customto remove methanol
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-2c608e5c93774fffbf61e71820397010
出典データセット
uspto-grants-2014_01
特許番号
US08629278B2

反応ノート

読み込み中…