tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate → tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate

HRID 470617ノート

反応式

HRID 470617 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]#[N:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][C:15]#[N:16])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 15326949tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate2 回

生成物 1

HCID 22248390tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

4-Cyanomethylene-piperidine-1-carboxylic acid tert-butyl ester (compound of Example 14; 6.9 g, 31.0 mmol) and Pd/C (0.7 g) in ethanol (150 mL) was maintained under hydrogen atmosphere for 8 h. The reaction mixture was filtered through Celite and the solvent was evaporated to afford the title compound.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-818dcfa918dd4a16a8512cc81129a5aa
出典データセット
uspto-grants-2014_01
特許番号
US08629277B2

反応ノート

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