Toluene → N'-hydroxyhexanimidamide

To a solution of 0.107 g (15.4 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 1.90 g (22.64 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 1.0 g (10.2 mmol) of hexanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After the reaction period, the reaction mixtures was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue. The residue with chased with 5 mL of toluene, to yield the title compound.

1. stirringstirred at 80° C. to 85° C. for 3-4 h
2. customAfter the reaction period
3. customthe reaction mixtures
4. temperaturewas cooled to 25° C. to 30° C.
5. filtrationfiltered
6. washwashed with 2 mL of isopropyl alcohol
7. customThe filtrate was collected
8. distillationdistilled out completely
9. customto obtain a crude residue

ORDレコード

ord-78c50ea9f043450bbc4ac28dbc99e005

出典データセット

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08629277B2