Toluene → N'-hydroxynonanimidamide

To a solution of 0.74 g (10.7 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 1.327 g (17.8 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 1.0 g (7.1 mmol) of nonanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After the reaction period, the reaction mixture was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue. The residue with chased with 5 mL of toluene below 45° C., under vacuum, to yield the title compound.

1. stirringstirred at 80° C. to 85° C. for 3-4 h
2. customAfter the reaction period
3. temperaturethe reaction mixture was cooled to 25° C. to 30° C.
4. filtrationfiltered
5. washwashed with 2 mL of isopropyl alcohol
6. customThe filtrate was collected
7. distillationdistilled out completely
8. customto obtain a crude residue

ORDレコード

ord-d41592d5c71f4ecb8defc356914eac8c

出典データセット

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08629277B2