Toluene → HCID 178443684、化合物
反応式
Cl.[NH2:2][OH:3].C(=O)(O)[O-].[Na+].[C:9](#[N:17])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C1(C)C=CC=CC=1>C(O)(C)C>[OH:3][NH:2][C:9](=[NH:17])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]参加物
6
実験手順
To a solution of 1.66 g (23.9 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 2.95 g (35.1 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 2.0 g (15.97 mmol) of octanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After completion of the reaction, the reaction mixture was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled to obtain a crude residue. The residue was chased with 5 mL of toluene, to yield the title compound.
後処理
- stirringstirred at 80° C. to 85° C. for 3-4 h
- customAfter completion of the reaction
- temperaturethe reaction mixture was cooled to 25° C. to 30° C.
- filtrationfiltered
- washwashed with 2 mL of isopropyl alcohol
- customThe filtrate was collected
- distillationdistilled
- customto obtain a crude residue
出典と根拠
- ORDレコード
- ord-d0becfbc743c4a3a8e2de2895be29912
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08629277B2
反応ノート
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