Ethyl formate → HCID 178486553、化合物
反応式
[Na].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[CH2:7]2.[CH:16](OCC)=[O:17]>C(O)C>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[C:7]2=[CH:16][OH:17]参加物
5
実験手順
To a warm solution of 1.5 g. sodium in 35 ml. ethanol was added 10 g. of 5,6-dimethoxy oxindole [J. Am. Chem. Soc. 77 3844 (1955)]. Then 30 ml. ethyl formate was added. A solid formed. The mixture was stirred and heated 10 minutes. A stream of nitrogen was blown over the mixture to evaporate as much solvent as possible. Then a solution of 6.5 ml. concentrated hydrochloric acid and 50 ml. water was added. The resulting clear solution was concentrated in vacuum and the resulting solid filtered and washed with ice water. Yield: 10.55 g., m.p. 216°-217° C.
後処理
- customA solid formed
- temperatureheated 10 minutes
- customto evaporate as much solvent as possible
- additionwater was added
- concentrationThe resulting clear solution was concentrated in vacuum
- filtrationthe resulting solid filtered
- washwashed with ice water
出典と根拠
- ORDレコード
- ord-eb5a423b340c4000879925cde7a6170a
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04176191
反応ノート
読み込み中…