1-Piperazinecarboxylic acid, ethyl ester → 5,6-Dimethoxy-3(4-carbethoxy piperazino)methylene oxindole
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15]O.[C:17]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)([O:19][CH2:20][CH3:21])=[O:18]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15][N:25]1[CH2:24][CH2:23][N:22]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:27][CH2:26]1参加物
3
実験手順
4.0 g. of 5,6-dimethoxy-3-hydroxymethylene oxindole was reacted with N-carbethoxy piperazine as described in Example 2, except that 0.10 g. toluene sulfone acid was added as a catalyst. Yield, 3.05 g. of product, m.p. 172°-174° C.
後処理
- customYield
出典と根拠
- ORDレコード
- ord-f04b5cd13a0348399248d9d826df7a49
- 出典データセット
- uspto-grants-1979_11