Triethylamine → 1,2,4-Oxadiazole, 5-cyclopropyl-3-(isocyanomethyl)-
反応式
[CH:1]1([C:4]2[O:8][N:7](C)[CH:6](NC=O)[N:5]=2)[CH2:3][CH2:2]1.[CH2:13]([N:15](CC)[CH2:16]C)C.O=P(Cl)(Cl)Cl.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl.O>[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH2:16][N+:15]#[C-:13])[N:5]=2)[CH2:2][CH2:3]1参加物
7
実験手順
A stirred solution of 5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged dropwise with POCl3 (60 mmol) at 0° C. The mixture was then left for 30 min. with stirring at 0° C., whereafter a solution of Na2CO3 (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, whereafter the organic phase was separated, dried and evaporated in vacuo. The residue was treated with ether, decanted and the solution was evaporated to give the title compound as an oil.
後処理
- additionwas added
- customwas separated
- customdried
- customevaporated in vacuo
- additionThe residue was treated with ether
- customdecanted
- customthe solution was evaporated
出典と根拠
- ORDレコード
- ord-99eb61288cb4458ca343c64c8408c1ff
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04727153
反応ノート
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