Methanol → Benzeneethanol, 3-(bromomethyl)-
反応式
CSC.B.[Br:5][CH2:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](O)=[O:15])[CH:10]=[CH:11][CH:12]=1.CO>C1COCC1>[Br:5][CH2:6][C:7]1[CH:8]=[C:9]([CH2:13][CH2:14][OH:15])[CH:10]=[CH:11][CH:12]=1参加物
5
実験手順
Borane dimethylsulphide complex (2M solution in THF, 5.78 mL) was added dropwise to a solution of 2-(3-(bromomethyl)phenyl)acetic acid (1.06 g) in THF (10 mL) at 0° C. and the resulting mixture stirred for 10 min. The reaction was then allowed to warm to room temperature and stirred overnight. Methanol (5 mL) was then added and the mixture concentrated in vacuo. Purification was by silica gel chromatography eluting with isohexane to diethyl ether gradient to give the subtitled compound as a white solid. Yield 1 g.
後処理
- stirringstirred overnight
- concentrationthe mixture concentrated in vacuo
- customPurification
- washeluting with isohexane to diethyl ether gradient
出典と根拠
- ORDレコード
- ord-2ad67469a81d4a00a5fbada5e063f898
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08629271B2
反応ノート
読み込み中…