Chloroform → 4,4-Dimethyl-7-(2,4-dimethoxybenzoyl amino)-8-nitro-2H,4H-isoquinoline-1,3-dione

HRID 47105

反応式

HRID 47105 の反応式
[CH3:1][C:2]1([CH3:18])[C:11]2[C:6](=[C:7]([N+:13]([O-:15])=[O:14])[C:8]([NH2:12])=[CH:9][CH:10]=2)[C:5](=[O:16])[NH:4][C:3]1=[O:17].C(Cl)(Cl)Cl.[CH3:23][O:24][C:25]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:26]=1[C:27](Cl)=[O:28]>C(N(CC)CC)C>[CH3:1][C:2]1([CH3:18])[C:11]2[C:6](=[C:7]([N+:13]([O-:15])=[O:14])[C:8]([NH:12][C:27](=[O:28])[C:26]3[CH:30]=[CH:31][C:32]([O:34][CH3:35])=[CH:33][C:25]=3[O:24][CH3:23])=[CH:9][CH:10]=2)[C:5](=[O:16])[NH:4][C:3]1=[O:17]

参加物

5

反応物 3

HCID 6212ChloroformHCID 27347192,4-Dimethoxybenzoyl chlorideHCID 111184431,3(2H,4H)-Isoquinolinedione, 7-amino-4,4-dimethyl-8-nitro-

生成物 1

HCID 203849914,4-Dimethyl-7-(2,4-dimethoxybenzoyl amino)-8-nitro-2H,4H-isoquinoline-1,3-dione

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

2.7 gm of 4,4-dimethyl-7-amino-8-nitro-2H,4H-isoquinoline-1,3-dione were admixed with 50 ml of chloroform and 2.5 ml of triethylamine. Subsequently, 2.2 gm of 2,4-dimethoxybenzoylchloride were added, and the mixture was refluxed for 2 hours. After cooling the solution was evaporated and the precipitate was suction-filtered off and digested with water while heating.

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureAfter cooling the solution
  3. customwas evaporated
  4. filtrationthe precipitate was suction-filtered off
  5. temperaturewhile heating

出典と根拠

ORDレコード
ord-4daf93f3d00e408d87d772158b269ff5
出典データセット
uspto-grants-1979_11
特許番号
US04176184

関連ノート

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