Hydrochloric Acid → 2-Cyclobutylthiazole-4-carboxylic acid

HRID 471120

反応式

HRID 471120 の反応式
O.[OH-].[Li+].[CH:4]1([C:8]2[S:9][CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=2)[CH2:7][CH2:6][CH2:5]1.Cl>C1COCC1.O>[CH:4]1([C:8]2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[CH2:5][CH2:6][CH2:7]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate

生成物 1

HCID 200843232-Cyclobutylthiazole-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Lithium hydroxide monohydrate (0.38 g) was added to a solution of ethyl 2-cyclobutylthiazole-4-carboxylate (example 58, step b) (0.48 g) in a mixture of THF (8 mL) and water (2 mL). The resulting suspension was stirred overnight at RT. The reaction was acidified with aqueous HCl solution (2M, 5 mL) and evaporated to dryness. The residue was partitioned between brine (5 mL) and ethyl acetate (20 mL). The layers were separated and the aqueous phase extracted with ethyl acetate (2×20 mL). The combined organic solutions were dried over sodium sulphate, filtered and evaporated to give the subtitled compound as a white solid. Yield 0.38 g.

後処理

  1. customevaporated to dryness
  2. customThe residue was partitioned between brine (5 mL) and ethyl acetate (20 mL)
  3. customThe layers were separated
  4. extractionthe aqueous phase extracted with ethyl acetate (2×20 mL)
  5. dry with materialThe combined organic solutions were dried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-429f5daeeaab4e7cab08a06e928ae83c
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

関連ノート

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