化工社化工社 化学情報印刷レポート · 研究参考用
N-Iodosuccinimide → 5-Iodo-6-(trifluoromethyl)pyridin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Iodosuccinimide | HCID 120273 | — |
| 反応物 | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| 生成物 | 5-Iodo-6-(trifluoromethyl)pyridin-2-amine | HCID 58073065 | — |
反応手順
The title compound is synthesized according to general procedure GP1 starting from 4.8 g (30 mmol) 6-trifluoromethyl-pyridin-2-ylamine and 6.7 g (30 mmol) NIS. Yield after precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography in silica gel: 5.73 g (67%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08633183B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-e63083d2adb44062b01f7509973f862e |
| 出典メモ | uspto-grants-2014_01 |