N-bromobutanimide → 4-bromo-5-methoxy-2,3-dihydro-1H-inden-1-one

HRID 471434ノート

反応式

HRID 471434 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6]2.[Al].[Br:14]N1C(=O)CCC1=O>O>[Br:14][C:4]1[C:3]([O:2][CH3:1])=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2=[O:12]

参加物

5

反応物 3

HCID 67184N-bromobutanimideHCID 787875-Methoxyindan-1-oneHCID 5359268Aluminum

生成物 1

HCID 378189874-bromo-5-methoxy-2,3-dihydro-1H-inden-1-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5-Methoxy-indane-1-one (17.2 g, 106.05 mmol) is suspended in 100 mL of water. The flask is covered with an aluminium foil to create a dark environment. N-Bromo-succinimide (18.87 g, 106.05 mmol) is added portionwise and the reaction mixture is stirred at room temperature overnight. The reaction mixture is extracted with 200 mL of ethyl acetate, the organic phase is collected, dried over sodium sulfate and concentrated under vacuum. The crude product obtained (20 g) is used in the next step without any further treatment.

後処理

  1. extractionThe reaction mixture is extracted with 200 mL of ethyl acetate
  2. customthe organic phase is collected
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-cba5939f0b054985826a413ac0332291
出典データセット
uspto-grants-2014_01
特許番号
US08633182B2

反応ノート

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