4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide → 4-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

HRID 471442ノート

反応式

HRID 471442 の反応式
[N+:1]([C:4]1[C:17]([CH3:18])=[CH:16][C:7]([C:8]([NH:10][CH2:11][C:12]([OH:15])([CH3:14])[CH3:13])=[O:9])=[CH:6][C:5]=1[CH3:19])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:5]([CH3:19])=[CH:6][C:7]([C:8]([NH:10][CH2:11][C:12]([OH:15])([CH3:13])[CH3:14])=[O:9])=[CH:16][C:17]=1[CH3:18]

参加物

4

反応物 1

HCID 867038834-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

生成物 1

HCID 867038844-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide収率 84.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide (1.2 g, 4.51 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% palladium on activated carbon (120 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 900 mg).

後処理

  1. filtrationThe mixture is filtered through celite
  2. customthe solvent removed under vacuum

出典と根拠

ORDレコード
ord-67c5733925104d7ca320afd798f14b04
出典データセット
uspto-grants-2014_01
特許番号
US08633182B2

反応ノート

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