N,3,5-Trimethyl-4-nitrobenzamide → 4-amino-N,3,5-trimethylbenzamide

HRID 471447ノート

反応式

HRID 471447 の反応式
[N+:1]([C:4]1[C:13]([CH3:14])=[CH:12][C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:6][C:5]=1[CH3:15])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:5]([CH3:15])=[CH:6][C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:12][C:13]=1[CH3:14]

参加物

4

反応物 1

HCID 86697180N,3,5-Trimethyl-4-nitrobenzamide

生成物 1

HCID 668742744-amino-N,3,5-trimethylbenzamide収率 99.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

4-Nitro-3,5,N-trimethyl-benzamide (1.0 g, 4.8 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% Palladium on activated carbon (100 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 850 mg).

後処理

  1. filtrationThe mixture is filtered through celite
  2. customthe solvent removed under vacuum

出典と根拠

ORDレコード
ord-4c035677036649519800a4b9ee9957a0
出典データセット
uspto-grants-2014_01
特許番号
US08633182B2

反応ノート

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