Nitric Acid → HCID 178512576、化合物

HRID 47204

反応式

HRID 47204 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+]([O-])=O)[CH:3]=1.[N+:12]([O-:15])([OH:14])=[O:13].[N:16]#[C:17][NH2:18]>CCO>[N+:12]([O-:15])([OH:14])=[O:13].[OH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:17]([NH2:18])=[NH:16])=[C:3]([N+:12]([O-:15])=[O:13])[CH:4]=1

参加物

5

反応物 3

HCID 944Nitric AcidHCID 9864CyanamideHCID 34174194-Amino-2-Nitrophenol

生成物 1

HCID 178512576HCID 178512576、化合物収率 54%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-amino-2-nitrophenol (25 mmol, 3.85 g) in EtOH (6 mL) on an ice bath was treated with nitric acid (69% aq soln.; 1.8 mL). To this of cyanamide (50% aq. soln.; 4 mL) was added. The reaction mixture was refluxed under N2 for 22 h. The solvent was evaporated. The dark brown solid residue was washed with EtOH and was dried under high vacuum to afford the title compound as a grey solid (3.53 g, 54%).

後処理

  1. temperatureThe reaction mixture was refluxed under N2 for 22 h
  2. customThe solvent was evaporated
  3. washThe dark brown solid residue was washed with EtOH
  4. customwas dried under high vacuum

出典と根拠

ORDレコード
ord-1668630a45044138b5579a1df16f23ff
出典データセット
uspto-grants-2004_03
特許番号
US06699854B2

関連ノート

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