Formaldehyde → 3-(5-Dimethylamino-3H-isobenzofuran-1-ylidene)-1-piperidin-1-ylmethyl-1,3-dihydro-indol-2-one

HRID 47250ノート

反応式

HRID 47250 の反応式
[CH3:1][N:2]([CH3:22])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][C:13]1=[O:21])[O:7][CH2:6]2.[CH2:23]=O.[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>CCO>[CH3:1][N:2]([CH3:22])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:23][N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[C:13]1=[O:21])[O:7][CH2:6]2

参加物

5

反応物 3

HCID 712FormaldehydeHCID 8082PiperidineHCID 688381003-(5-Dimethylamino-3H-isobenzofuran-1-ylidene)-1,3-dihydro-indol-2-one

生成物 1

HCID 688397743-(5-Dimethylamino-3H-isobenzofuran-1-ylidene)-1-piperidin-1-ylmethyl-1,3-dihydro-indol-2-one収率 89.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3-(5-Dimethylamino-3H-isobenzofuran-1-ylidene)-1,3-dihydro-indol-2-one (550 mg, 1.88 mmol), paraformaldehyde (141 mg, 4.7 mmol) and piperidine (240 mg, 2.82 mmol) in 20 mL of EtOH was stirred at reflux for overnight and cooled to room temperature. The solid which formed on cooling was collected by filtration, washed with EtOH (5 mL) and dried under vacuum to give the title compound (655 mg, 89%) as bright yellow crystals.

後処理

  1. temperatureat reflux for overnight
  2. customThe solid which formed
  3. temperatureon cooling
  4. filtrationwas collected by filtration
  5. washwashed with EtOH (5 mL)
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-e0da936273f9471982e27b5874bc5979
出典データセット
uspto-grants-2004_03
特許番号
US06699863B1

反応ノート

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