Methyl 6-(((trifluoromethyl)sulfonyl)oxy)-1-naphthoate → HCID 66660876、化合物

HRID 472781ノート

反応式

HRID 472781 の反応式
FC(F)(F)S(O[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([C:17]([O:19][CH3:20])=[O:18])=[CH:12][CH:11]=[CH:10]2)(=O)=O.[CH2:23]([Mg]Br)[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>C1COCC1.CN1C(=O)CCC1.CCOCC>[CH2:23]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([C:17]([O:19][CH3:20])=[O:18])=[CH:12][CH:11]=[CH:10]2)[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

参加物

6

反応物 2

HCID 22622428Methyl 6-(((trifluoromethyl)sulfonyl)oxy)-1-naphthoateHCID 178444609HCID 178444609、化合物

生成物 1

HCID 66660876HCID 66660876、化合物収率 76%

試薬・触媒・溶媒 3

HCID 3283Diethyl Ether溶媒2 回HCID 8028Tetrahydrofuran溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

In accordance with the procedure of Furstner (Angew. Chem. Int. Ed., 2002, 41, 609-612), a solution of methyl 6-(((trifluoromethyl)sulfonyl)oxy)-1-naphthoate (334 mg, 1.0 mmol) and Fe(acac)3 in THF (6 mL) and NMP (0.56 mL) was treated with n-hexylmagnesium bromide (1.2 mL of a 2.0 M solution in Et2O, 2.4 mmol) at room temperature. After 30 min, the mixture was diluted with Et2O (20 mL) and quenched with 1 N aqueous HCl (5 mL). The phases were separated and the organic phase was washed with water (2×15 mL) and brine (15 mL), then dried (Na2SO4), filtered and concentrated in vacuo. The resulting residue was purified on 40 g silica gel (100% hexanes→20% EtOAc/hexanes, gradient) to afford 206 mg (76%) of methyl 6-hexyl-1-naphthoate.

後処理

  1. customquenched with 1 N aqueous HCl (5 mL)
  2. customThe phases were separated
  3. washthe organic phase was washed with water (2×15 mL) and brine (15 mL)
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe resulting residue was purified on 40 g silica gel (100% hexanes→20% EtOAc/hexanes, gradient)

出典と根拠

ORDレコード
ord-5a41c18c3c054799b94add1dc985435d
出典データセット
uspto-grants-2014_01
特許番号
US08633220B2

反応ノート

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