Methyl iodide → 1-Methoxy-2-(trifluoromethyl)benzene

HRID 47293

反応式

HRID 47293 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[C:12](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:12]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 679582-Trifluoromethylphenol

生成物 1

HCID 27752511-Methoxy-2-(trifluoromethyl)benzene収率 111.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 10 g 2-trifluoromethyl phenol, 17 g potassium carbonate, 150 ml acetone and 7.7 ml iodomethane was heated under reflux for 2 hr. After cooling, the insoluble matters were removed by filtration, and the filtrate was evaporated. The resulting residue was dissolved in ethyl acetate, and washed with water and brine. It was dried over anhydrous magnesium sulfate, filtered, and evaporated to give 12.15 g of 2-trifluoromethyl anisole.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hr
  3. temperatureAfter cooling
  4. customthe insoluble matters were removed by filtration
  5. customthe filtrate was evaporated
  6. dissolutionThe resulting residue was dissolved in ethyl acetate
  7. washwashed with water and brine
  8. dry with materialIt was dried over anhydrous magnesium sulfate
  9. filtrationfiltered
  10. customevaporated

出典と根拠

ORDレコード
ord-53767db6e48047baad2d6662a8734f6d
出典データセット
uspto-grants-2004_03
特許番号
US06699870B2

関連ノート

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