Tetrahydrofuran → HCID 68473560、化合物

HRID 473072

反応式

HRID 473072 の反応式
[CH3:1][C:2]1([CH2:16][O:17][Si:18]([CH2:23][CH3:24])([CH2:21][CH3:22])[CH2:19][CH3:20])[CH2:10][C:9]2[C:4](=[C:5]([CH3:14])[C:6]([CH:12]=[CH2:13])=[C:7]([CH3:11])[CH:8]=2)[CH:3]1[OH:15].B(C1CCCCC1)C1CCCCC1.C1C[O:41]CC1>>[OH:41][CH2:13][CH2:12][C:6]1[C:5]([CH3:14])=[C:4]2[C:9]([CH2:10][C:2]([CH3:1])([CH2:16][O:17][Si:18]([CH2:23][CH3:24])([CH2:21][CH3:22])[CH2:19][CH3:20])[CH:3]2[OH:15])=[CH:8][C:7]=1[CH3:11]

参加物

4

反応物 3

HCID 8028TetrahydrofuranHCID 15879360CID 15879360HCID 68475157HCID 68475157、化合物

生成物 1

HCID 68473560HCID 68473560、化合物収率 81%

実験手順

To the stirred solution of compound 8 (0.85 g, 2.45 mmol) in dry THF was added (Cy)2BH (0.87 g, 4.91 mmol) slowly at 0° C. under argon atmosphere. The reaction mixture was warmed to room temperature and stirred for 12 h. The reaction mixture was quenched with 2N NaOH (6 mL) and H2O2 (3 mL) at 0° C. and allowed to stir for 4 h. Then crude reaction mixture was extracted with ethyl acetate (40 mL), washed with water (10 mL), brine (10 mL) dried (Na2SO4) and concentrated in vacuo. Purification by column chromatography (SiO2, 8 to 10% EtOAc in petroleum ether eluant) gave pure compound 9 (0.72 g, 81%) as gummy syrup.

後処理

  1. customThe reaction mixture was quenched with 2N NaOH (6 mL) and H2O2 (3 mL) at 0° C.
  2. stirringto stir for 4 h
  3. customThen crude reaction mixture
  4. extractionwas extracted with ethyl acetate (40 mL)
  5. washwashed with water (10 mL), brine (10 mL)
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated in vacuo
  8. customPurification by column chromatography (SiO2, 8 to 10% EtOAc in petroleum ether eluant)

出典と根拠

ORDレコード
ord-ffcdd68e47104200a9b3c4395ec2e520
出典データセット
uspto-grants-2014_01
特許番号
US08633252B2

関連ノート

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