Hydrochloric Acid → HCID 70220203、化合物

HRID 473112ノート

反応式

HRID 473112 の反応式
[CH3:1][CH:2]([S:4]([NH:7][C@@H:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]([O:19]C)=[O:18])[CH:14]=2)[CH2:9]1)(=[O:6])=[O:5])[CH3:3].[OH-].[Li+].CCOC(C)=O.Cl>O.CO>[CH3:3][CH:2]([S:4]([NH:7][C@@H:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]([OH:19])=[O:18])[CH:14]=2)[CH2:9]1)(=[O:6])=[O:5])[CH3:1]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8857Ethyl AcetateHCID 66733844(S)-methyl 2-(1-methylethylsulfonamido)-2,3-dihydro-1H-indene-5-carboxylate

生成物 1

HCID 70220203HCID 70220203、化合物収率 78.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A mixture of (S)-methyl 2-(1-methylethylsulfonamido)-2,3-dihydro-1H-indene-5-carboxylate (2.320 mmol, 690 mg) and lithium hydroxide (5.10 mmol, 122 mg) in H2O (25 mL) and MeOH (25 mL) was stirred at room temp for 2 days. EtOAc was added followed by 2M aq HCl and the reaction mixture extracted with EtOAc (×3). The EtOAc layers were combined and washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give desired product as a white solid (514 mg, 78%). MS (ESI): m/z [M−H]− 282.2

後処理

  1. extractionthe reaction mixture extracted with EtOAc (×3)
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-c40b9c0fdd1a4568a457c71355560854
出典データセット
uspto-grants-2014_01
特許番号
US08633237B2

反応ノート

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