3-Nitropicolinaldehyde → 3-Aminopyridine-2-carbaldehyde

HRID 473434

反応式

HRID 473434 の反応式
[N+:1]([C:4]1[C:5]([CH:10]=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[C:5]([CH:10]=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 3293613-Nitropicolinaldehyde

生成物 1

HCID 122040093-Aminopyridine-2-carbaldehyde収率 50%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 3-nitropicolinaldehyde (500 mg, 3.28 mmol) in EtOH (10 mL) was added Pd/C (50 mg) under nitrogen atmosphere. The reaction mixture was stirred for overnight under hydrogen atmosphere. The reaction mixture was filtered through cilite and washed with EtOH. The filtrate was concentrated in vacuo to give 3-aminopicolinaldehyde (200 mg, 50% yield): 1H NMR (400 MHz, DMSO-d6) δ 7.132 (br s, 2H), 7.217-7.325 (m, 2H), 7.979 (dd, J=1.6 Hz, J=4.0 Hz, 1H), 9.899 (s, 1H); LC-MS (ESI) m/z 123.0 [M+H]+.

後処理

  1. filtrationThe reaction mixture was filtered through cilite
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-7bc10bd860ce42e69d3338afce772368
出典データセット
uspto-grants-2014_01
特許番号
US08633313B2

関連ノート

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