Hydrogen Bromide → 5-Bromo-3-Methylpentanoic Acid

A solution of β-methyl-δ-valerolactone (3.0 g) in anhydrous dichloromethane (30 ml), cooled to 0-5° C., was saturated with hydrogen bromide gas and the mixture was stirred for three days at room temperature. The mixture was diluted with dichloromethane (100 ml) and the resulting solution was washed with 10-% NaCl (3×30 ml). Next the solution was dried with anhydrous MgSO4 and the solvent was distilled under reduced pressure, Yield 4.6 g. NMR ˜100% pure product.

1. washthe resulting solution was washed with 10-% NaCl (3×30 ml)
2. dry with materialNext the solution was dried with anhydrous MgSO4
3. distillationthe solvent was distilled under reduced pressure, Yield 4.6 g

ORDレコード

ord-95917679d23b46ad8d20952589db3386

出典データセット

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08637466B2