Hydrochloric Acid → 4-(Dibenzylamino)butanoic acid

HRID 473604ノート

反応式

HRID 473604 の反応式
C([O:3][C:4](=[O:23])[CH2:5][CH2:6][CH2:7][N:8]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)C.Cl>C1COCC1>[CH2:16]([N:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:7][CH2:6][CH2:5][C:4]([OH:23])=[O:3])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 13929784Ethyl 4-(Dibenzylamino)butanoate

生成物 1

HCID 146277764-(Dibenzylamino)butanoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 500 mg (1.6 mmol, 1 equiv.) of 4-dibenzylamino-butyric acid ethyl ester in 1 ml of THF was added 4 ml of HCl 2N and the resulting mixture was stirred for 48 hours. After decantation and separation, the aqueous layer was extracted twice by ethyl acetate. The pH was fixed to 5 using solid sodium carbonate and the aqueous layer was extracted by dichloromethane. The dichloromethane layer was dried over sodium sulphate, evaporated and used without further purification.

後処理

  1. customAfter decantation and separation
  2. extractionthe aqueous layer was extracted twice by ethyl acetate
  3. extractionthe aqueous layer was extracted by dichloromethane
  4. dry with materialThe dichloromethane layer was dried over sodium sulphate
  5. customevaporated
  6. customused without further purification

出典と根拠

ORDレコード
ord-592d667beef04324878fc26cb879470e
出典データセット
uspto-grants-2014_01
特許番号
US08637496B2

反応ノート

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