2-(1-Benzylpyrrolidin-3-yl)propan-2-ol → 2-(Pyrrolidin-3-yl)propan-2-ol

HRID 473618ノート

反応式

HRID 473618 の反応式
C([N:8]1[CH2:12][CH2:11][CH:10]([C:13]([OH:16])([CH3:15])[CH3:14])[CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].CCO>[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]([OH:16])([CH3:15])[CH3:14])[CH2:9]1

参加物

5

反応物 2

HCID 69147642-(1-Benzylpyrrolidin-3-yl)propan-2-olHCID 178418361HCID 178418361、化合物

生成物 1

HCID 139001662-(Pyrrolidin-3-yl)propan-2-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A pressure vessel was charged with 2-(1-benzylpyrrolidin-3-yl)propan-2-ol (1.013 g, 4.62 mmol), palladium, 10 wt. % (dry basis) on activated carbon (wet) (0.904 g, 0.425 mmol) and EtOH (20 mL). The reaction vessel was pressurized (50 psi) with hydrogen and purged 3 times. The vessel was pressurized at 50 psi and allowed to stir overnight at rt. The reaction was filtered and the filtrate was concentrated to dryness.

後処理

  1. custompurged 3 times
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate was concentrated to dryness

出典と根拠

ORDレコード
ord-29d3792d19f94b2ebb50d098a63ef16a
出典データセット
uspto-grants-2014_01
特許番号
US08637500B2

反応ノート

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