Sodium Hydroxide → 7,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid

HRID 47362

反応式

HRID 47362 の反応式
C([O:3][C:4]([CH:6]1[CH:15]2[CH2:16][CH:17]=[CH:18][CH:14]2[C:13]2[C:12]([Cl:19])=[CH:11][C:10]([Cl:20])=[CH:9][C:8]=2[NH:7]1)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:20][C:10]1[CH:11]=[C:12]([Cl:19])[C:13]2[CH:14]3[CH:18]=[CH:17][CH2:16][CH:15]3[CH:6]([C:4]([OH:5])=[O:3])[NH:7][C:8]=2[CH:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 98832257,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester

生成物 1

HCID 29147727,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Compound 1 was saponified with 1.0 ml sodium hydroxide solution (6N, water) in 20.0 ml ethanol. The ethanolic solution was concentrated to small volume on a rotary evaporator, the residue was taken up in water, reacted with 6N HCl and the aqueous solution extracted three times over ether. The organic phase was washed neutral with water, dried over magnesium sulphate and concentrated to a reduced volume on a rotary evaporator.

後処理

  1. concentrationThe ethanolic solution was concentrated to small volume on a rotary evaporator
  2. customreacted with 6N HCl
  3. extractionthe aqueous solution extracted three times over ether
  4. washThe organic phase was washed neutral with water
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated to a reduced volume on a rotary evaporator

出典と根拠

ORDレコード
ord-cf3b603d4cea4b518d3f7d1107febe51
出典データセット
uspto-grants-2004_03
特許番号
US06699877B2

関連ノート

読み込み中…