2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine → 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

HRID 473677ノート

反応式

HRID 473677 の反応式
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:12]([F:13])=[N:11][CH:10]=[CH:9][N:8]=2)[CH2:3][CH2:2]1>CCOC(C)=O.[OH-].[OH-].[Pd+2]>[F:13][C:12]1[C:7]([CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:8][CH:9]=[CH:10][N:11]=1

参加物

4

反応物 1

HCID 593511782-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine

生成物 1

HCID 593512282-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a round-bottomed flask was added 2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine (1.1754 g, 6.52 mmol) and palladium hydroxide on carbon (0.458 g, 0.652 mmol) in EtOAc (21.75 mL). The reaction mixture was flushed with argon and then placed under vacuum three times. A hydrogen balloon was then attached to the reaction. After stirring overnight, the reaction mixture was filtered through celite and concentrated in vacuo to give the title compound. MS (ESI, pos. ion) m/z: 183.1.

後処理

  1. customThe reaction mixture was flushed with argon
  2. customA hydrogen balloon was then attached to the reaction
  3. filtrationthe reaction mixture was filtered through celite and
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-cf8551b3d76b4c059eab820300919940
出典データセット
uspto-grants-2014_01
特許番号
US08637500B2

反応ノート

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