Methyl iodide → 6-Bromo-1-methyl-1H-indazole

HRID 473783

反応式

HRID 473783 の反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.[OH-].[K+].[CH3:13]I>CO.C(OCC)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:13])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 178424716-Bromo-1H-indazole

生成物 1

HCID 225586756-Bromo-1-methyl-1H-indazole

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.

後処理

  1. temperaturethe mixture was refluxed for 2.5 h
  2. temperatureThe reaction was cooled
  3. washwashed with water, brine
  4. customdried
  5. concentrationconcentrated
  6. customThe product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash

出典と根拠

ORDレコード
ord-615be3596a7d4ecc8f70f7e5d3a21df5
出典データセット
uspto-grants-2014_01
特許番号
US08637497B2

関連ノート

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