Trifluoroacetic acid → 4-(Trifluoromethyl)-4-piperidinol
反応式
[OH:1][C:2]1([C:15]([F:18])([F:17])[F:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[F:18][C:15]([F:16])([F:17])[C:2]1([OH:1])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1参加物
4
実験手順
To a solution of tert-butyl 4-hydroxy-4-(trifluoromethyl)piperidine-1-carboxylate (0.07 g, 0.26 mmol) in dichloromethane (1 mL) was added trifluoroacetic acid (1 mL). The resulting mixture was stirred at room temperature for 30 minutes. Concentration and drying afforded 4-(trifluoromethyl)piperidin-4-ol (0.044 g, 100%). MS (EI) for C6H10F3NO: 269 (MH+).
後処理
- concentrationConcentration
- customdrying
出典と根拠
- ORDレコード
- ord-d5b6dad348254f1ca77bc12e6316ee05
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637499B2
反応ノート
読み込み中…