HCID 131731162、化合物 → rel-(2R,6S)-2-Methyl-6-(trifluoromethyl)morpholine
反応式
C([N:8]1[CH2:13][C@@H:12]([CH3:14])[O:11][C@H:10]([C:15]([F:18])([F:17])[F:16])[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:18][C:15]([F:16])([F:17])[C@H:10]1[O:11][C@H:12]([CH3:14])[CH2:13][NH:8][CH2:9]1参加物
5
実験手順
N-benzyl-trans-2-trifluoromethyl-6-methylmorpholine [1223452-62-7] (7.5 g, 28.93 mmol) was added to a suspension of Pd/C 10% (1 g) in methanol (150 mL). The reaction mixture was stirred at room temperature under a hydrogen atmosphere until 1 equivalent of hydrogen was absorbed. The catalyst was removed by filtration over diatomaceous earth. The solvent was evaporated, yielding 3.3 g (67%) of Intermediate 30 as an oil that was used without further purification.
後処理
- customwas absorbed
- customThe catalyst was removed by filtration over diatomaceous earth
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-01d325a6a63c413dad091ad2bdb671a3
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637510B2
反応ノート
読み込み中…