N-tert-butyl-1-benzhydryl-3-methylazetidin-3-amine hydrochloride → HCID 68455629、化合物
反応式
[ClH:1].[C:2]([NH:6][C:7]1([CH3:24])[CH2:10][N:9](C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:8]1)([CH3:5])([CH3:4])[CH3:3]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:1].[C:2]([NH:6][C:7]1([CH3:24])[CH2:10][NH:9][CH2:8]1)([CH3:5])([CH3:4])[CH3:3]参加物
4
反応条件
- 温度
- 40 °C
実験手順
To a slurry of N-tert-butyl-1-benzhydryl-3-methylazetidin-3-amine hydrochloride (1.69 g, 4.91 mmol) in ethanol (30 ml) was added 10% Palladium hydroxide on carbon (160 mg) and the mixture degassed three times with nitrogen and three times with hydrogen. The mixture was then stirred under a hydrogen atmosphere 40° C. (warm water bath) for 3 h and then at room temperature for a further 12 h. The reaction was degassed with nitrogen and filtered through celite and concentrated. The compound was used crude in subsequent chemistry. 1H NMR (MeOH) 1.50 (9H, s), 1.99 (3H, s), 4.19 (2H, d), 4.91 (2H, d).