Potassium tert-butoxide → 5-(6-Bromo-pyridin-2-yl)-5-methyl-morpholin-3-one

HRID 474036ノート

反応式

HRID 474036 の反応式
[Br:1][C:2]1[N:7]=[C:6]([C:8]([NH:12][C:13](=[O:16])[CH2:14]Cl)([CH3:11])[CH2:9][OH:10])[CH:5]=[CH:4][CH:3]=1.CC([O-])(C)C.[K+]>C(O)(C)(C)C>[Br:1][C:2]1[N:7]=[C:6]([C:8]2([CH3:11])[NH:12][C:13](=[O:16])[CH2:14][O:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 23665647Potassium tert-butoxideHCID 86668009N-[1-(6-bromo-pyridin-2-yl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

生成物 1

HCID 866680115-(6-Bromo-pyridin-2-yl)-5-methyl-morpholin-3-one

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

To a solution of N-[1-(6-bromo-pyridin-2-yl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide in tert-butanol (90 ml) was added KOtBu and the reaction mixture was stirred at rt for 4 h. The reaction mixture was quenched with H2O and diluted with EtOAc. The phases were separated and the aq. phase was twice extracted with EtOAc. The combined org. phases were washed with brine, dried over Na2SO4, filtered and the solvent was removed to leave the title compound as a pale yellow solid. HPLC RtH4=0.73 min; ESIMS: 271, 273 [(M+H)+]; 1H NMR (400 MHz, DMSO-d6): δ 8.72 (s, 1H), 7.82-7.78 (m, 1H), 7.57-7.51 (m, 2H), 4.10 (d, 2H), 4.00 (d, 1H), 3.65 (d, 1H), 1.42 (s, 3H).

後処理

  1. customThe reaction mixture was quenched with H2O
  2. additiondiluted with EtOAc
  3. customThe phases were separated
  4. extractionthe aq. phase was twice extracted with EtOAc
  5. washphases were washed with brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. customthe solvent was removed

出典と根拠

ORDレコード
ord-e1be45d67bb2423eb35d22a18732224b
出典データセット
uspto-grants-2014_01
特許番号
US08637508B2

反応ノート

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