Hydrochloric Acid → [4-(3-Cyclopropylpyrazin-2-yl)phenyl]acetic acid

HRID 474145

反応式

HRID 474145 の反応式
[CH:1]1([C:4]2[C:5]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]C)=[O:18])=[CH:12][CH:11]=3)=[N:6][CH:7]=[CH:8][N:9]=2)[CH2:3][CH2:2]1.[Li+].[OH-].Cl>CO>[CH:1]1([C:4]2[C:5]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=3)=[N:6][CH:7]=[CH:8][N:9]=2)[CH2:2][CH2:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59535940Methyl [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetate

生成物 1

HCID 59535939[4-(3-Cyclopropylpyrazin-2-yl)phenyl]acetic acid収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 0.10 g (0.37 mmol) of methyl [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetate in 0.75 ml of MeOH was added 0.75 mL (0.75 mmol) of 1N LiOH. After 1 h at room temperature, the reaction mixture was acidified with 1 N HCl, extracted twice with ethyl acetate. The combined organic layers were washed with brine. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo to afforded 0.080 g (84%) of [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetic acid. ES-MS M+1=255.1.

後処理

  1. extractionextracted twice with ethyl acetate
  2. washThe combined organic layers were washed with brine
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d717518d453149938a13cc4a466f6cf3
出典データセット
uspto-grants-2014_01
特許番号
US08637513B2

関連ノート

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