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Tetrahydrofuran → 2-(4-(2-Cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Fluoro-4-nitrobenzonitrile | HCID 2759048 | — |
| 反応物 | 2-(3,4-Dihydroxybutyl)isoindoline-1,3-dione | HCID 21592489 | — |
| 生成物 | 2-(4-(2-Cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid | HCID 66665258 | — |
反応手順
2-(3,4-dihydroxybutyl)isoindoline-1,3-dione was reacted as described in Intermediate Y(2) with sodium hydride and 2-fluoro-4-nitrobenzonitrile in THF to get 2-(4-(2-cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid which is used as-is in the next step. LC-MS (M+H)+=400.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08637523B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-a21c3b254e9a4dbd835dc04487976639 |
| 出典メモ | uspto-grants-2014_01 |