反应详情

2-(3,4-dihydroxybutyl)isoindoline-1,3-dione was reacted as described in Intermediate Y(2) with sodium hydride and 2-fluoro-4-nitrobenzonitrile in THF to get 2-(4-(2-cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid which is used as-is in the next step. LC-MS (M+H)+=400.1.