Sodium Hydroxide → 8-Fluoro-2-methoxy-4-quinolinecarboxylic acid

HRID 47432ノート

反応式

HRID 47432 の反応式
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([O:16][CH3:17])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[N:8]=[C:7]([O:16][CH3:17])[CH:6]=[C:5]2[C:3]([OH:4])=[O:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 544876468-Fluoro-2-methoxyquinoline-4-carboxylic Acid Methyl Ester

生成物 1

HCID 227451438-Fluoro-2-methoxy-4-quinolinecarboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

8-Fluoro-2-methoxyquinoline-4-carboxylic acid methyl ester (0.1 82 g) in methanol (10 ml) containing 2N sodium hydroxide (0.41 ml) was stirred at room temperature for 16 h. Solvent was removed at reduced pressure, dissolved in water, and adjusted to pH2 with 2N hydrochloric acid. The precipitated title compound (0.155 g) was collected by filtration and dried. m/z (API−): 222 (MH+). 1H NMR δ: 4.02 (3H, s), 7.44-7.62 (3H, m), 8.31 (1H, d).

後処理

  1. customSolvent was removed at reduced pressure
  2. dissolutiondissolved in water
  3. customThe precipitated title compound (0.155 g)
  4. filtrationwas collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-99e2d3b1335843f0a3515c01d591ba7d
出典データセット
uspto-grants-2004_03
特許番号
US06699879B1

反応ノート

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