2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester → HCID 54346018、化合物

HRID 47438ノート

反応式

HRID 47438 の反応式
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:5]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1

参加物

5

反応物 2

HCID 540755342-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 54346018HCID 54346018、化合物収率 96.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

The compound of step 1 (2.3 g) in methanol (150 ml) containing 10% Pd/C (0.5 g) was hydrogenated under one atmosphere of hydrogen for 18 h. The mixture was filtered (kieselguhr) and solvent removed from the filtrate under reduced pressure to give the title compound (2.0 g) as a yellow oil. 1H NMR (CDCl3) δ: 3.69 (2H, brs), 3.77 (6H, s), 6.76-6.87 (6H, m), 7.19 (1H, d, J=2.5 Hz).

後処理

  1. filtrationThe mixture was filtered (kieselguhr) and solvent
  2. customremoved from the filtrate under reduced pressure

出典と根拠

ORDレコード
ord-aaf8ecbfeabc41609627124b2c8edee2
出典データセット
uspto-grants-2004_03
特許番号
US06699879B1

反応ノート

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