Nitric Acid → N-methyl-6-nitro-1,3-benzoxazol-2-amine
反応式
[CH3:1][NH:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[N+:12]([O-])([OH:14])=[O:13]>>[CH3:1][NH:2][C:3]1[O:4][C:5]2[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1参加物
3
実験手順
2-Methylaminobenzoxazole (2.0 g, Hetzheim, Annemarie; Schlaak, G.; Kerstan, Christa., Pharmazie, (1987), 42, 80) was added in portions to conc. nitric acid (15 ml) at room temperature. Stirring was continued over 8 h. The reaction mixture was poured onto crushed ice/sodium hydrogen carbonate with vigorous stirring. The precipitated title compound (1.76 g) was collected by filtration and dried in vacuo at 40° C. m/z (API+): 194 (MH+).
後処理
- additionThe reaction mixture was poured
- customThe precipitated title compound (1.76 g)
- filtrationwas collected by filtration
- customdried in vacuo at 40° C. m/z (API+)
出典と根拠
- ORDレコード
- ord-943d03d05fe64ca280d2c39889409359
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699879B1
反応ノート
読み込み中…