methyl (2E)-3-(pyrimidin-5-yl)prop-2-enoate → Methyl 3-(pyrimidin-5-yl)propanoate

HRID 474543ノート

反応式

HRID 474543 の反応式
[N:1]1[CH:6]=[C:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10])[CH:4]=[N:3][CH:2]=1>CO.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:4]=[N:3][CH:2]=1

参加物

4

反応物 1

HCID 18470237methyl (2E)-3-(pyrimidin-5-yl)prop-2-enoate

生成物 1

HCID 18470121Methyl 3-(pyrimidin-5-yl)propanoate収率 92.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of methyl (2E)-3-(5-pyrimidinyl)-2-propenoate (19.2 g, 117 mmol) and Pd/C (2 g, 1.879 mmol) in methanol (100 mL) was stirred under H2 at 50° C. overnight. The mixture was filtered through a pad of celite and concentrated to give the crude title compound as yellow oil (18 g, 55.6% yield). LCMS: rt=1.11 min, [M+H+]=167

後処理

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-c77d9593e92e4cfab70f3c89c785d9fe
出典データセット
uspto-grants-2014_01
特許番号
US08637536B2

反応ノート

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