Chlorosulfonic acid → 2-Chlorosulfonyl-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoic acid, methyl ester

HRID 4746

反応式

HRID 4746 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]([F:27])([F:26])[C:8]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:16][CH:15]=1)([OH:13])[C:9]([F:12])([F:11])[F:10]>>[Cl:1][S:2]([C:18]1[CH:19]=[C:14]([C:8]([OH:13])([C:9]([F:12])([F:11])[F:10])[C:7]([F:6])([F:26])[F:27])[CH:15]=[CH:16][C:17]=1[CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])(=[O:5])=[O:3]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 20151856Methyl 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoate

生成物 1

HCID 867420032-Chlorosulfonyl-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoic acid, methyl ester

実験手順

To excess chlorosulfonic acid cooled with an ice-acetone bath can be added methyl 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoate with stirring. The solution should be stirred for several hours. Addition of the reaction mixture to ice and isolation of the product will give 2-chlorosulfonyl-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoic acid, methyl ester. Reduction of 2-chlorosulfonyl-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoic acid, methyl ester with zinc in acetic acid followed by isolation of the product will give 2-mercapto-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepropanoic acid, methyl ester.

後処理

  1. stirringThe solution should be stirred for several hours
  2. additionAddition of the reaction mixture to ice and isolation of the product

出典と根拠

ORDレコード
ord-325adc1ebbbf4db88aa4a692c9efebaa
出典データセット
uspto-grants-1988_02
特許番号
US04727180

関連ノート

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