(E)-2-Methoxy-4-styrylpyrimidine → HCID 58093434、化合物

HRID 475000ノート

反応式

HRID 475000 の反応式
[CH3:1][O:2][C:3]1[N:8]=[C:7](/[CH:9]=[CH:10]/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1

参加物

4

反応物 1

HCID 58093422(E)-2-Methoxy-4-styrylpyrimidine

生成物 1

HCID 58093434HCID 58093434、化合物収率 97.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (E)-2-methoxy-4-styrylpyrimidine (0.51 g, 2.4 mmol) in methanol (25 mL) was added palladium on carbon (0.18 g). The reaction mixture was stirred under hydrogen balloon for 3 days and then filtered through a pad of celite. The filtrate was concentrated under reduced pressure to provide the title compound (0.50 g, 97%) as a colorless oil: 1H NMR (500 MHz, CDCl3) δ 8.35 (d, J=5.0 Hz, 1H), 7.29-7.26 (m, 2H), 7.21-7.18 (m, 3H), 6.72 (d, J=5.0 Hz, 1H), 4.02 (s, 3H), 3.08-2.98 (m, 4H).

後処理

  1. filtrationfiltered through a pad of celite
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-32d0a202e8864127bf2451e775911a56
出典データセット
uspto-grants-2014_01
特許番号
US08637501B2

反応ノート

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