Hydroxyamine hydrochloride → 1-(2-Bromophenyl)propan-2-one oxime
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=O)[CH3:10].CC([O-])=O.[Na+].Cl.[NH2:18][OH:19]>CO>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[N:18][OH:19])[CH3:10]参加物
5
実験手順
To a mixture of 1-(2-bromophenyl)propan-2-one (1.5 g, 7.04 mmol) and NaOAc (693 mg, 8.45 mmol) in MeOH (50 mL) at RT was added hydroxylamine hydrochloride (539 mg, 7.8 mmol). After the reaction mixture was stirred at RT for 18 h, it was concentrated in vacuo. Water was added (100 mL), and the mixture was extracted with EtOAc (50 mL×3), dried (MgSO4) and concentrated in vacuo to afford 1-(2-bromophenyl)propan-2-one oxime as a yellow solid (1.51 g, 94%). MS (ESI): m/z=228.1 [M+1]+.
後処理
- concentrationit was concentrated in vacuo
- additionWater was added (100 mL)
- extractionthe mixture was extracted with EtOAc (50 mL×3)
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-cf554ec425784c5488491af913c1a488
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637537B2
反応ノート
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