Hydroxyamine hydrochloride → HCID 136336869、化合物

HRID 475167ノート

反応式

HRID 475167 の反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:11])=[C:4]([C:12](=O)[CH3:13])[CH:3]=1.Cl.[NH2:16][OH:17].CC([O-])=O.[Na+]>CCO>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:11])=[C:4]([C:12](=[N:16][OH:17])[CH3:13])[CH:3]=1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 86694714HCID 86694714、化合物

生成物 1

HCID 136336869HCID 136336869、化合物収率 87.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

To the solution of 1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone (900 mg, 4.68 mmol) in EtOH (20 mL) was added hydroxylamine hydrochloride (1.64 g, 23.4 mmol, 5.0 eq.) and NaOAc (3.84 g, 46.8 mmol, 10 eq.). The mixture was stirred at 40° C. overnight, and the solvent was concentrated in vacuo to afford 1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone oxime as a white solid (848 mg, 87%). MS (ESI): m/z=208.2 [M+1]+.

後処理

  1. concentrationthe solvent was concentrated in vacuo

出典と根拠

ORDレコード
ord-b5c1a9679594480c94b066ae6c264968
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

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