Formic Acid → 5-bromo-4-chloro-1H-benzoimidazole

HRID 475221ノート

反応式

HRID 475221 の反応式
[Br:1][C:2]1[C:3]([Cl:10])=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[OH-].[Na+].[CH:13](O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][CH:13]=[N:9][C:4]=2[C:3]=1[Cl:10]

参加物

4

反応物 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 578001544-Bromo-3-chlorobenzene-1,2-diamine

生成物 1

HCID 594744835-bromo-4-chloro-1H-benzoimidazole収率 78%

実験手順

A mixture of 4-bromo-3-chloro-benzene-1,2-diamine (CASRN 1008361-80-5, 27 g, 0.1221 mol) and formic acid (80 mL) was heated to reflux for 1.5 h. After the completion of the reaction, 10% NaOH was added until the solution basic. The resulting solid was filtered and washed well with water then dried over night over suction to afford 22 g (78%) of 5-bromo-4-chloro-1H-benzoimidazole (128) as pale yellow solid which was used without additional purification.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 1.5 h
  3. additionwas added until the solution basic
  4. filtrationThe resulting solid was filtered
  5. washwashed well with water
  6. customthen dried over night over suction

出典と根拠

ORDレコード
ord-2152470eec4c4135a9f5aaa1666b2842
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

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