Formic Acid → 5-bromo-4-fluoro-1H-1,3-benzodiazole

HRID 475227ノート

反応式

HRID 475227 の反応式
[Br:1][C:2]1[C:3]([F:10])=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[OH-].[Na+].[CH:13](O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][CH:13]=[N:9][C:4]=2[C:3]=1[F:10]

参加物

4

反応物 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 27832034-Bromo-3-fluorobenzene-1,2-diamine

生成物 1

HCID 594744775-bromo-4-fluoro-1H-1,3-benzodiazole収率 92%

実験手順

A mixture of 142 (25 g, 0.121 mol) and formic acid (75 mL) was heated to reflux for 1.5 h. After the completion of the reaction the reaction was cooled and made basic with 10% NaOH. The resulting solid was filtered and washed with water. Drying overnight under suction afforded 24 g (92%) of 5-bromo-4-fluoro-1H-benzoimidazole (144) as pale yellow solid which was used without further purification.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 1.5 h
  3. customAfter the completion of the reaction the reaction
  4. temperaturewas cooled
  5. filtrationThe resulting solid was filtered
  6. washwashed with water
  7. customDrying overnight under suction

出典と根拠

ORDレコード
ord-f1583a4b3fe34a2290845f9da677cef6
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

反応ノート

読み込み中…