関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (1-methyl-1H-indol-5-yl)methylamine | HCID 18525752 | — |
| 反応物 | 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 58169118 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | HCID 71272215 | HCID 71272215 | — |
反応手順
A microwave vial was charged with 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine (160 mg, 0.68 mmol), 296 (800 mg, 5.59 mmol), DIPEA (1 ml), and IPA (5.0 mL), sealed and heated at 120° C. for 18 h. It was concentrated and purified by SiO2 chromatography, and then preparative HPLC to afford 30 mg (12%) of I-33 as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08637537B2 |
|---|
| 出典データセット | uspto-grants-2014_01 |
|---|
| ORD ID | ord-f0bb7d6be6034ea0984653c6e25a8990 |
|---|
| 出典メモ | uspto-grants-2014_01 |
|---|
