Trimethylsilyl iodide → Methyl(5r)-5-propynyl-l-prolinate
反応式
[C:1]([C@@H:4]1[N:8](C(OC)=O)[C@H:7]([C:13]([O:15][CH3:16])=[O:14])[CH2:6][CH2:5]1)#[C:2][CH3:3].I[Si](C)(C)C>C(Cl)(Cl)Cl>[C:1]([C@@H:4]1[NH:8][C@H:7]([C:13]([O:15][CH3:16])=[O:14])[CH2:6][CH2:5]1)#[C:2][CH3:3]参加物
4
実験手順
A solution of dimethyl(2S,5R)-5-propynyl-pyrrolidine-1,2-dicarboxylate (4.25 g, 18.90 mmol) and iodotrimethylsilane (3.23 mL, 22.7 mmol, Example 85A) in chloroform (60 mL) was heated to 65° C. for 3 hours, was cooled to room temperature, concentrated under reduced pressure and flash chromatographed with 35% ethyl acetate/65% hexane to provide the titled compound. MS (DCI/NH3) m/e 168 (M+H)+.
後処理
- concentrationconcentrated under reduced pressure and flash
- customchromatographed with 35% ethyl acetate/65% hexane
出典と根拠
- ORDレコード
- ord-2c1e9e53d9db4afbb25ed331652a2217
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637546B2
反応ノート
読み込み中…