1,2-Dichloroethane → HCID 58713642、化合物

反応式

[O:1]=[C:2]1[CH2:22][C:5]2[C:6]([C:19]([OH:21])=[O:20])=[N:7][N:8]([S:9]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=3)(=[O:11])=[O:10])[C:4]=2[CH2:3]1.O[N:24]1[C:28](=[O:29])[CH2:27][CH2:26][C:25]1=[O:30].C(Cl)CCl>C(Cl)Cl>[O:30]=[C:25]1[CH2:26][CH2:27][C:28](=[O:29])[N:24]1[O:20][C:19]([C:6]1[C:5]2[CH2:22][C:2](=[O:1])[CH2:3][C:4]=2[N:8]([S:9]([C:12]2[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=2)(=[O:11])=[O:10])[N:7]=1)=[O:21]

参加物

実験手順

To a solution of the intermediate from step C above, (320 mg, 1.0 mmol) in CH2Cl2(20 mL) was added N-hydroxy succinimide (230 mg, 2.0 mmol) followed by EDC (384 mg, 2.0 mmol). After stirring at room temperature for 18 hours, the reaction mixture was concentrated in vacuo. The residue was diluted with ethyl acetate (20 mL), washed with saturated NaHCO3, solution and brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. A yellow solid was obtained.