Pivalaldehyde → N-neopentylidene-L-alanine ethyl ester

HRID 47595

反応式

HRID 47595 の反応式
[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[NH2:6])[CH3:2].[O-]S([O-])(=O)=O.[Mg+2].[CH:15](=O)[C:16]([CH3:19])([CH3:18])[CH3:17]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[N:6]=[CH:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:2]

参加物

5

反応物 3

HCID 12417PivalaldehydeHCID 24083Sulfuric acid magnesium salt (1:1)HCID 76507L-Alanine ethyl ester

生成物 1

HCID 11412788N-neopentylidene-L-alanine ethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Step-2. L-Alanine ethyl ester from step-1 (9 g) was dissolved in 150 ml anhydrous CH2Cl2. The solution was cooled to 0° C. MgSO4 (10.17 g) was added to the solution followed by addition of pivalaldehyde (6.95 g). The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was filtered and the filtrate was evaporated to give 11.2 g of N-neopentylidene-L-alanine ethyl ester. The product was used for next step without further purification. MS: 186 (MH+).

後処理

  1. temperatureto warm to room temperature
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-ab9b76fdbc7743159f62fc351f2ad4f3
出典データセット
uspto-grants-2004_03
特許番号
US06699888B2

関連ノート

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