1-Cyclopentyloxy-2-methoxy-5-nitrobenzene → 3-(Cyclopentyloxy)-4-methoxyaniline

HRID 47600

反応式

HRID 47600 の反応式
[CH:1]1([O:6][C:7]2[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[CH:9][C:8]=2[O:16][CH3:17])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[Pd]>[CH:1]1([O:6][C:7]2[CH:12]=[C:11]([CH:10]=[CH:9][C:8]=2[O:16][CH3:17])[NH2:13])[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

4

反応物 1

HCID 113907411-Cyclopentyloxy-2-methoxy-5-nitrobenzene

生成物 1

HCID 27793343-(Cyclopentyloxy)-4-methoxyaniline収率 95.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a suspension of 10% Pd on activated carbon (25 g) in ethanol (4L), under N2 protection, was added 1-cyclopentyloxy-2-methoxy-5-nitrobenzene (250 g, 1.054 mol). The reaction mixture was degassed under vacuum three times. The reaction mixture was stirred vigorously while hydrogen gas was allowed to flow over the reaction mixture. After 4 h the reaction was complete by TLC (5:1 hex:EA). The reaction mixture was filtered through a pad of celite and the celite was rinsed with additional ethanol. The solvent was removed in-vacuo to obtain 208.38 g (95% yield) of 3-cyclopentyloxy-4-methoxyaniline as a red liquid. 1H NMR (CDCl3) δ 6.85 (d. J=8.4 Hz, 1H), 6.29 (s, 1H), 6.19 (dd, J=2.8, 8.4, 1H), 4.69 (p, J=4.4 Hz, 1H), 3.75 (s, 3H), 3.44 (bs, 2H),1.90-1.81 (m, 6H), 1.61-1.55 (m, 2H).

後処理

  1. customThe reaction mixture was degassed under vacuum three times
  2. filtrationThe reaction mixture was filtered through a pad of celite
  3. washthe celite was rinsed with additional ethanol
  4. customThe solvent was removed in-vacuo

出典と根拠

ORDレコード
ord-a78c2e88d66048de9707ae4a9542d381
出典データセット
uspto-grants-2004_03
特許番号
US06699890B2

関連ノート

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